#159909 Radnoti Micrometer Adapter Assembly
Designed in response to researchers’ requests to add the capability of precise measurements of tissue length, we proudly offer the 159909 Radnoti Micrometer Adapter for use with the Radnoti Transducer Positioner.
In combination, they are an excellent means of plotting muscle length/tension curves to permit comparisons of different muscle types and normalizing force output due to variations in muscle size. Length/tension curves are derived by gradually stretching and then relaxing a muscle, for example, a smooth muscle ring section measuring force generated at a given length and then plotting a series of such measurements as length versus force. After determining and then subtracting the elements of passive force due to the elastic components of the muscle, the result is a curve that can be used to determine a stretching force (pre-load) that holds the muscle at its optimum length (Lo), permitting the muscle to perform at its peak tension (Po)- Additionally, the measurement of the stretched length of the muscle, with area calculations made using muscle mass or the measured width (diameter), together with the force generated permits the calculation of stress (dynes/cm2). Stress measurements can then be used to compare the absolute performance of different muscle types or various sizes obtained under different conditions or disease states.
These procedures were originally reported in a paper by J.T. Herlihy and R.A. Murphy in Circulation Research 33:275-283, 1973.
The Radnoti design allows the researcher to make these measurements using a simple add-on micrometer adapter to our popular transducer positioner.
The micrometer adapter consist of a collar which slides into the transducer positioner opening where the transducer is normally inserted. The collar holds a 25mm locking vernier which precisely measures displacement to 0.01mm. The transducer is then attached to the bottom of the micrometer. To use the system, the transducer holder is adjusted so that the vernier can move the transducer. The transducer is adjusted so that the force equals 0, i.e. the muscle support wire weight is nulled out. The bath is then lowered and the muscle attached. If necessary, a slight tensioning of the vernier to remove slack is used to hold the muscle in place. The bath is raised so that the muscle is submerged in the bath solution, the vernier adjusted to stretch the muscle, force is generated, and the curve constructed.
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